Non-Clinical Evaluation Center

Experience the excellence

*N-CEC proudly announces that it has become one of the council member recognized by the Korea Health Industry Development Institute (KHIDI).* *Validity evaluation service council selected by KHIDI working efficiently to revolutionize basic and intermediary research in new drugs and medical devices.*


History drives the future

Feel the distinct excellence in our research and thoughts

N-CEC believes in integrated research, where basic research provides the firm background for future Non-clinical trials. Thoughts and understandings gained from basic research is fundamental to success. Hence, N-CEC immersed itself in basic research through its network and collaborators. Over the years, N-CEC has published several research articles in highly reputed journals.


Ongoing Projects




Completed Projects



Here are the recent publications

  • Lee HY, Lee GH, Hoang TH, Park SA, Lee J, Lim J, et al. D-allulose ameliorates hyperglycemia through IRE1alpha sulfonation-RIDD-SIRT1 decay axis in the skeletal muscle. Antioxid Redox Signal. 2022.
  • Lee HY, Lee GH, Yoon Y, Hoang TH, Chae HJ. IBF-R Regulates IRE1alpha Post-Translational Modifications and ER Stress in High-Fat Diet-Induced Obese Mice. Nutrients. 2022;14(1).
  • Lee GH, Cheng P, Lee H-Y, Park S-A, Hoang T-H, Kim JH, et al. D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats. Food & Nutrition Research. 2021;65.
  • Hoang T-H, Yoon Y, Park S-A, Lee H-Y, Peng C, Kim J-H, et al. IBF-R, a botanical extract of Rhus verniciflua controls obesity in which AMPK-SIRT1 axis and ROS regulatory mechanism are involved in mice. Journal of Functional Foods. 2021;87:104804.
  • Park, S.A., Lee, G.H.; Hoang, T.H.; Lee, H.Y.; Kang, I.Y.; Chung, M.J.; Jin, J.S.; Chae, H.J. Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats. PLoS One 2021, 16, e0250354, doi:10.1371/journal.pone.0250354.
  • Lee GH, Hoang TH, Jung ES, Jung SJ, Han SK, Chung MJ, et al. Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats. Aging Cell. 2020;19(12):e13279.
  • Park, S.A., et al., Glucose-lowering effect of Gryllus bimaculatus powder on streptozotocin-induced diabetes through the AKT/mTOR pathway. Food Sci Nutr, 2020. 8(1): p. 402-409.
  • Lee, H.Y., et al., Phosphatidylinositol 3-kinase-delta controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. Br J Pharmacol, 2020. 177(7): p. 1556-1567.
  • Lee, H.Y., et al., The correlation of IRE1alpha oxidation with Nox4 activation in aging-associated vascular dysfunction. Redox Biol, 2020. 37: p. 101727.
  • Lee, H.Y., et al., Ixeris dentata and Lactobacillus gasseri Extracts Improve Salivary Secretion Capability in Diabetes-Associated Dry Mouth Rat Model. Nutrients, 2020. 12(5).
  • Lee, H.Y., et al., Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients, 2020. 12(3).
  • Kim, H.K., et al., TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy, 2020: p. 1-18.
  • Kim, H.K., et al., TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun, 2020. 11(1): p. 4012.
  • Park, S., et al., Isolation of amylase regulators from the leaves of Ixeridium dentatum. Nat Prod Res, 2019: p. 1-6.
  • Lee, H.Y., et al., R. verniciflua and E. ulmoides Extract (ILF-RE) Protects against Chronic CCl(4)-Induced Liver Damage by Enhancing Antioxidation. Nutrients, 2019. 11(2).
  • Lee, H.Y., et al., Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation. Am J Chin Med, 2019. 47(6): p. 1253-1270.
  • Lee, H.Y., et al., Platycodi Radix and its active compounds ameliorate against house dust mite-induced allergic airway inflammation and ER stress and ROS by enhancing anti-oxidation. Food Chem Toxicol, 2019. 123: p. 412-423.
  • Lee, H.Y., et al., Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function. Nutrients, 2019. 11(2).
  • Lee, H.Y., et al., Mulberry Extract Attenuates Endothelial Dysfunction through the Regulation of Uncoupling Endothelial Nitric Oxide Synthase in High Fat Diet Rats. Nutrients, 2019. 11(5).