Non-Clinical Evaluation Center

Experience the excellence


History drives the future

Feel the distinct excellence in our research and thoughts

N-CEC believes in integrated research, where basic research provides the firm background for future Non-clinical trials. Thoughts and understandings gained from basic research is fundamental to success. Hence, N-CEC immersed itself in basic research through its network and collaborators. Over the years, N-CEC has published several research articles in highly reputed journals.


Ongoing Projects




Completed Projects



Here are the recent publications

  • Park, S.A.,   et al., Glucose-lowering effect of Gryllus bimaculatus powder on streptozotocin-induced diabetes through the AKT/mTOR pathway. Food Sci Nutr, 2020. 8(1): p. 402-409.
  • Lee, H.Y., et al.,   Phosphatidylinositol 3-kinase-delta controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. Br J Pharmacol, 2020. 177(7): p. 1556-1567.
  • Lee, H.Y., et al.,   The correlation of IRE1alpha oxidation with Nox4 activation in aging-associated vascular dysfunction. Redox Biol, 2020. 37: p. 101727.
  • Lee, H.Y., et al.,   Ixeris dentata and Lactobacillus gasseri Extracts Improve Salivary Secretion Capability in Diabetes-Associated Dry Mouth Rat Model. Nutrients, 2020. 12(5).
  • Lee, H.Y., et al.,   Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients, 2020. 12(3).
  • Kim, H.K., et al.,   TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy, 2020: p. 1-18.
  • Kim, H.K., et al.,   TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun, 2020. 11(1): p. 4012.
  • Park, S., et al.,   Isolation of amylase regulators from the leaves of Ixeridium dentatum. Nat Prod Res, 2019: p. 1-6.
  • Lee, H.Y., et al.,   R. verniciflua and E. ulmoides Extract (ILF-RE) Protects against Chronic CCl(4)-Induced Liver Damage by Enhancing Antioxidation. Nutrients, 2019. 11(2).
  • Lee, H.Y., et al.,   Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation. Am J Chin Med, 2019. 47(6): p. 1253-1270.
  • Lee, H.Y., et al.,   Platycodi Radix and its active compounds ameliorate against house dust mite-induced allergic airway inflammation and ER stress and ROS by enhancing anti-oxidation. Food Chem Toxicol, 2019. 123: p. 412-423.
  • Lee, H.Y., et al.,   Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function. Nutrients, 2019. 11(2).
  • Lee, H.Y., et al.,   Mulberry Extract Attenuates Endothelial Dysfunction through the Regulation of Uncoupling Endothelial Nitric Oxide Synthase in High Fat Diet Rats. Nutrients, 2019. 11(5).